Wales make two other changes to the team which beat Italy - prop Gethin Jenkins has been ruled out with a calf injury suffered in Rome so Paul James comes in, and Alun Wyn Jones replaces Andrew Coombs in the second row.
Ryan Jones retains the captaincy for Saturday's match after taking the armband against France and Italy when Warburton started on the bench.
Wales will be chasing a victory which is likely to set up a title decider with England in Cardiff.
Wales' interim head coach Rob Howley retains the same back division for a fourth successive game, but three changes on the bench from Rome see Cardiff Blues prop Scott Andrews come in for James, with Coombs and Justin Tipuric swapping places with Jones and Warburton respectively.
"Ryan has led the team to two wins and deserves to captain the side against Scotland," Howley said.
"We have spoken a lot about momentum in this tournament, and we go into the game with two wins under our belt, but Scotland are in the same position and it's going to be a good challenge."
Howley added: "We have had two good, hard-fought away victories, but we know we will have to be at our best again to come away from Murrayfield with the result.
"It's disappointing for Gethin to miss out, but Paul has impressed and made an impact in each game he has played.
"We are bringing in a wealth of experience with Alun-Wyn and Sam, and they both performed well off the bench in Rome."
Team: L Halfpenny (Cardiff Blues); A Cuthbert (Cardiff Blues), J Davies (Scarlets), J Roberts (Cardiff Blues); G North (Scarlets); D Biggar (Ospreys), M Phillips (Bayonne); P James (Bath), R Hibbard (Ospreys), A Jones (Ospreys), A-W Jones (Ospreys), I Evans (Ospreys), R Jones (Ospreys, capt), S Warburton (Cardiff Blues), T Faletau (Newport Gwent Dragons).
Replacements: K Owens (Scarlets), S Andrews (Cardiff Blues), C Mitchell (Exeter), A Coombs (Newport Gwent Dragons), J Tipuric (Ospreys), L Williams (Cardiff Blues), J Hook (Perpignan), S Williams (Scarlets).
Source : http://www1.skysports.com/rugby-union/news/12507/8541891/Sam-Warburton-returns-as-Wales-change-three-for-Scotland-showdown
